ABSTRACT
Background:The current coronavirus disease 2019 (COVID-19) pandemic, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has posed a significant public health concern throughout the world, putting millions of people at risk in an increasing number of nations.Due to the development of endothelial dysfunction, coagulopathy, cytokine storm, and plaque instability, COVID-19 is recognized as an independent risk factor for cardiovascular illnesses.The goal of this study was to look at blood levels of interleukin 6 (IL-6), lipid profiles, ferritin, C-reactive protein (CRP), D-dimer, lymphocytes, and neutrophils in COVID-19 patients, as well as the relationship between IL-6 and biochemical predictor values for COVID-19 severity. Materials andMethods: In this case-control study,total of 60 COVID 19 patients within 1 week of displaying COVID19 symptoms and SARS-CoV-2 specific RT-PCR was verified. of Nasopharyngeal (NP) swab specimen were recruited.ageranged between(30-50 years)To compare the results, (60) apparently healthy persons of the same ages and sexes were included in this study ascontrol group.All of the patents and healthy persons were made to suffer to the estimation of serume IL-6, D-Dimer, CRP, ferritin,lipid profiles, andanthropometric data were analyzed. Results:Serum IL-6 level was higher in covid-19 patients group compared to healthy control group (812.32± 147.76vs. 148.95± 51.59ng/ mLp = 0.0001). Ferritin,CRP, and D-dimer serum levels were also higher in covid-19 patients compared to control group (p = 0.0001). as well as TC,LDL-C,and VLDL-C When compared to healthy controls, COVID-19 patients exhibited a substantial reduction in the levels studied in this study. We also discovered that IL-6 levels were higher significantly associated with the serum ferritin,D-dimer,TC, LDL-C, and CRP levels. Conclusion:The level of IL-6 was shown to be the most important predictor of outcome and a useful tool for prognostic assessment. The prevalence of atherogenic dyslipidaemia during infection was linked to a poorer COVID-19 infection outcome in a robust and independent way. Low HDL cholesterol and high triglyceride levels seen in covid-19 patients are strong indicators of the disease's severity. 1.
ABSTRACT
Background: SARS-Cov-2, the culprit responsible for the 2019 new coronavirus disease (COVID-19), has posed a serious threat to worldwide public health. At the moment, it is estimated that the novel coronavirus severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) has infected It has infected a huge number of people worldwide and is responsible for the clinical syndrome of coronavirus sickness 2019 (COVID-19). Although the primary clinical manifestation is pulmonary disease, mounting evidence supports the involvement of multiple organ systems, including the Gastro Intestinal (GI) tract and liver. To evaluate the potential changes in liver function tests, and their association with illness severity and mortality in patients with COVID-19. Materials and methods: This case-control study of 90 subjects were included, 60 patients admitted to Merjan Hospital, Babel, Iraq infected with COVID-19 and 30 samples of healthy subjects as a control group. The serum levels of ALT, AST, Alp, and albumin were measured by colorimetric methods. Serum ferritin and d-dimer were measured by ichroma, and CBC conducting a statistical analysis and associated with the severity of disease. Results: In this study, the results demonstrated a significant increase in levels of ALT, AST, ALP, ferritinin, and D-dimer in patients compared with the healthy group. Levels of serum ferritin have a significant positive correlation with D-dimer, ALP, AST, ALT, and NLR levels. While, it has a significant negative correlated with serum albumin in patients with corona virus group. The neutrophil percentage significantly higher than normal. While, the lymphocyte percentage was significantly lower in patients with elevated ferritin and d-dimer levels than the healthy group. Conclusion: COVID-19 patients with abnormal liver function testes are common in hospitalized patients with COVID-19, and associated with illness severity and rate of death as a higher incidence of severity illness and liver injury in patients with increased levels of serum ferritin, and D-dimer. © 2021 Norman WA, et al.